PCSK9 and inherited lipid metabolism disorder: There are two PCSK9 inhibiting monoclonal antibodies, alirocumab and evolocumab, administered every 2–4 weeks that were approved for treating dyslipidaemia and they have been effective lipid-lowering drugs with greater absolute risk-reduction for cardiovascular events particularly in patients with diabetes, decreasing LDL-C by 50–65% [2].