Consistent with a previous study20, the conditional KO (cKO) mice that received AAV-sgErbB4v1 spent less time in the open arms and had fewer entries into the open arms than the control virus-injected mice did, whereas both groups exhibited comparable locomotion (Fig. 2c–e), indicating increased anxiety when ErbB4 was deleted in CeLSST neurons. The gene discussed is ERBB4; the disease is Anxiety.