CDKN2A and cancer: Various cellular traits, such as induction of senescent cell death [40], loss-of-function of ERAS and a unique type of cellular senescence dependent on suppression of the tumor suppressor ARF [45], resistance to DNA damage [42], hypersensitive contact inhibition [64], and high translational fidelity [41], are suggested to potentially contribute to longevity, delayed aging, and cancer resistance in NMRs.