MSH6 and posterior cortical atrophy: Transurethral resection of prostate (Specimen 1) revealed high-grade prostate adenocarcinoma (Gleason 5 + 4 = 9) with genomic deletion of MSH2 by next generation sequencing (NGS) and loss of MSH2 and its binding partner MSH6 protein expression by immunohistochemistry (IHC), consistent with MMRd PCa.