The presence of CD1C (IVW OR = 0.804, 95% CI: 0.658 − 0.984, p = 0.034), IL1B (IVW OR = 0.846; 95% CI: 0.732–0.978; p = 0.024), and SLPI (IVW OR = 0.862; 95% CI: 0.751–0.990; p = 0.035) may be associated with a lower risk of COVID-19 (Fig. 3). This evidence concerns the gene IL1B and COVID-19.