Within the range of their varying functional properties, TAp73 proteins have tumour-suppressive activities of apoptosis and growth inhibition due to the presence of the p53-like TA domain, while ΔTAp73 isoforms lack the TA domain and have oncogenic functions, acting as transdominant inhibitors of TAp73, TAp63 and p5312,14,29–31. The gene discussed is TP53; the disease is neoplasm.