To test the importance of non-cancer cell Enpp1 expression in the response to radiation therapy, MC38 tumors were implanted into wt C67BL/6 or Enpp1−/− mice and, once established, mice were randomized to 12 Gy of radiation therapy delivered to the tumor by CT guidance or no further treatment (Fig. 3bi). The gene discussed is ENPP1; the disease is neoplasm.