STING1 and cancer: For the response to radiation therapy, a range of innate sensors expressed in immune cells such as TLRs, RIG-I, and STING detect the endogenous adjuvants released following radiation of cancer cells and help determine whether CD8 T cell responses are optimally incorporated to eliminate the surviving cancer cells, or whether CD8 T cell responses are not incorporated permitting regrowth of the tumor6–10.