ENPP1 and cancer: We compared Enpp1 expression across a panel of cancer cell lines in the Broad Institute Cancer Dependency Map (DepMap) (https://depmap.org/portal/)17, and found that while breast cancer cell lines and lung cancer cell lines had a relatively high expression of Enpp1, colorectal cancer cell lines had Enpp1 expression that was significantly lower than either (Fig. 1a).