In ovarian cancer SKOV3 and Hey cells, we found that (a) flutamide significantly upregulated the expression of miR-449a and miR-449b-5p, (b) introducing mimics of miR-449a and miR-449b-5p downregulated CSF1R and AR expression at both mRNA and protein levels, and (c) miR-449a and miR-449b-5p exhibited inhibitory effects on cell migration (Figs. 3, 4, 5 and 6; Suppl. The gene discussed is AR; the disease is ovarian cancer.