Pathological examination revealed that the majority of Ki-67- and MPO-negative cells immediately adjacent to C. albicans displayed morphological signs of necrosis, characterized by loss of cellular detail, indistinct cell borders, karyopyknosis, karyorhexis, karyolysis, and nuclear smearing, suggesting that the absence of TYK2 or its enzymatic activity increases neutrophil necrosis at the infection site. The gene discussed is MPO; the disease is infection.