Similar to our observations in Tyk2-/- and Tyk2K923E mice, Ifngr1-/- mice showed less pronounced changes in the white blood cell composition than WT mice (Fig. 5d), a better containment of C. albicans at the infection site, as indicated by GMS staining of skin sections (Fig. 5e), and the formation of a Ki-67-negative layer around the pathogen (Fig. 5f). Here, TYK2 is linked to infection.