Alternatively, zinc crystals bound to insulin molecules may cause neutrophilic chemotaxis, lysis of those neutrophils leading to enzyme release and further zinc dispersion, and increased chemotaxis in an inflammatory cycle [33, 46] Interestingly, the switch to MDI from CSII led to fewer reactions [33], which contradicts the finding of lipodystrophies [26, 28]. The gene discussed is INS; the disease is lipodystrophy.