POU2F1 deficiency led to higher levels of intracellular reactive oxygen species (ROS) and hypersensitivity to oxidative and genotoxic stress; as earlier mentioned, one of the mechanisms through which platinum compounds like cisplatin induces antitumor effects in HNSCC (Vázquez-Arreguín et al. 2019; Yu et al. 2020). Here, POU2F1 is linked to head and neck squamous cell carcinoma.