UNC5C and Alzheimer disease: In contrast, astrocytes upregulated genes related to Aβ toxicity (APP and CLU) and downregulated genes related to negative regulation of dephosphorylation (GSK3B, TGFB2, DLG2, and PTN) and other AD-related genes (GRM3, UNC5C, MAOB, and DPYSL2).