However, ciBAR1-KO mice mirror many of the exocrine pancreatic defects—loss of acinar cell architecture, lipomatosis, ductal hyperplasia, inflammation, and collagen deposition—observed in KO mouse models of genes involved in cilia assembly and function, such as Cby1, KIF3A, IFT88, PKD2, and inversin (Cano et al, 2004, 2006; Cyge et al, 2021). This evidence concerns the gene PKD2 and lipomatosis.