IGHE and airway hyperresponsiveness: The role of IL-13 signaling in asthma has been recognized for a long time in multiple studies [30–33], and IL-13 is a pleiotropic TH2 cytokine that has been considered as a key to the pathogenesis of asthma through its regulatory role in IgE synthesis, mucus hypersecretion, airway hyperresponsiveness, and fibrosis [31].