To explore the role of ZNF503-AS2 in glioma prognosis, we analyzed CGGA325 glioma datasets, and the results of univariate Cox regression analyses showed that tumor type, WHO grade, age, and ZNF503-AS2 expression were risk factors, whereas IDH mutation and 1p/19q co-deletions were protective factors. This evidence concerns the gene IDH1 and central nervous system cancer.