SP1 played an important role in drug resistance and tumor growth in glioma, and RELA and NF-kB1 are involved in carcinogenic activation through the NF-kB signaling pathway through enrichment analysis of the Transcriptional Regulatory Relationships Unraveled by Sentence-based Text mining (TRRUST) database (Fig 2G). This evidence concerns the gene NFKB1 and central nervous system cancer.