ZNF503 and central nervous system cancer: Based on the functional analysis of ZNF503-AS2, we found that ZNF503-AS2 promoted the activation of oncogenic pathways, stroma-associated pathways, and inflammatory responses, and the activation of stromal cells and production of inflammatory factors further altered the TME, which showed that ZNF503-AS2 could affect the glioma TME in various ways [40,41].