To further investigate the role of ZNF503-AS2 in the TME, we analyzed the gene set containing immune cells and immune functions, and the results showed that the high-expression group had higher immune cell infiltration and higher immunosuppression (Fig 3A), as well as higher stromal and immune scores and lower tumor purity (Fig 3B), suggesting that there may be a close link between ZNF503-AS2 and the TME of glioma. This evidence concerns the gene ZNF503 and central nervous system cancer.