With regards to ICC-related genes, the expression levels of the ligands of the c-Kit receptor tyrosine kinase, kitlb and the kit marker, CD44 were significantly upregulated in the ED model, whereas CD34, CD44, and the chloride channel–ANO1 were all significantly upregulated in the HFD model. This evidence concerns the gene ANO1 and intrahepatic cholangiocarcinoma.