PKM and acute kidney injury: Specifically, we found upregulation of glucose-6-phosphate isomerase (GPI), triosephosphate isomerase 1 (TPI1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase 1 (PGK1), phosphoglycerate mutase 1 (PGAM1), enolase 1 (ENO1), pyruvate kinase M1/2 (PKM), lactate dehydrogenase A (LDHA), and solute carrier family 16 member 3 (SLC16A3) in ECs from kidney tissues of patients with AKI compared with the control group (Figure 5E).