It is reported that inflammasomes promote the posttranslational modification of cytokines into their active forms via caspase-1, which mediates the chemotaxis and proliferation of immune cells, regulates the differentiation of CD4+ T cells into Th1 and Th17 cells and participates in the mechanism of occurrence and development of a variety of autoimmune diseases (32). This evidence concerns the gene CASP1 and autoimmune disease.