ERBB2 and cancer: Shoichet and co-workers designed PMs taking advantageof the Diels–Aldercycloaddition click reaction.244 The micellewas made of poly(2-methyl-2-carboxytrimethylene carbonate-co-d,l-lactide)-graft-PEG-furan (poly(TMCC-co-LA)-g-PEG-furan).In this, the furan groups are present at the outside of the micelles,and can take part in a subsequent Diels–Alder reaction withmaleimide-modified anti-HER2, a therapeutic antibody used to treatbreast cancer.