In the model adjusting for age, sex, race, APOE4, and cognitive/dementia status, we observed different trends of association depending on each vascular pathology; “arteriolosclerosis,” “atherosclerosis of the circle of Willis,” and “presence of any vascular pathology” were associated with more AD pathologies, including diffuse plaques, neuritic plaques, and NFT, while “large arterial infarcts,” “infarcts and lacunes,” and “one or more lacunes” tended to be associated with less these AD‐related pathologies (Table S1). The gene discussed is APOE; the disease is atherosclerosis.