In addition to other cargoes such as MeCP2 and NF-κB (Baker et al., 2015; Fagerlund et al., 2005; Lyst et al., 2018), NPAT is a novel cargo of KPNA3 and is involved in breast cancer and Hodgkin lymphoma (Kalla et al., 2007; Milne et al., 2017; Saarinen et al., 2011; Wright et al., 2017). The gene discussed is MECP2; the disease is breast cancer.