Other factors may also modulate STING-driven immune responses in the tumor microenvironment, including the cellular compartment(s) in which STING and/or IFN signaling are induced (e.g., DCs or malignant cells), the nature of antitumor T cell specificities and functionalities, and the density of antigen-presenting cells within the tumor. Here, STING1 is linked to neoplasm.