The extracellular matrix of ameloblastomas had been revealed to be determined by the neoplastic epithelium that expresses factors that positively control osteoclastogenesis, such as a receptor activator for nuclear factor κappa B ligand (RANKL) and interleukin (IL)-6, on the one hand, while also expressing factors, such as secreted-frizzled-related protein-2 that suppresses osteoblasts, on the other hand [43]. The gene discussed is TNFSF11; the disease is ameloblastoma.