However, they developed marked postprandial hyperglycaemia compared with the NGT group (mean 2 h glucose 8.3±1.0 vs 5.9±1.0 mmol/l; p<0.001; enhanced processing), with moderate hyperinsulinaemia (863.0±388.0 vs 580.4±487.1 pmol/l; p<0.001 suggesting an isolated defect in insulin sensitivity in the fed state. This evidence concerns the gene INS and Hyperglycemia.