Ly6Chigh monocytes have been shown to be precursors of monocytic myeloid-derived suppressor cells, which promote tumor growth and suppress immune cell functions in the microenvironment.29, 30, 31 In contrast, granulocytic CD45+CD11b+Ly6C−Ly6Ghigh cells were not affected by intervention or genotype. Here, ITGAM is linked to neoplasm.