Interestingly, under CD conditions, macroscopic tumor development occurred in 100% (8/8) of WT mice, but only 57% (4/7) of Il1r1Hep−/− mice at 30 weeks of age, and was paralleled by pronounced increases in serum ALT, AST, LDH, AFP levels, and liver weights in the WT DEN+CD group (Supplemental Figure S4 and S5, http://links.lww.com/HC9/B79). The gene discussed is GPT; the disease is neoplasm.