In general, we found no difference between serum (Figure 1F) and hepatic cytokine/chemokine levels (Supplemental Table S4, http://links.lww.com/HC9/B79) between Il1r1Hep−/− and WT mice, which might indicate, above all, intrinsic IL-1R1-dependent alterations in tumor cells. The gene discussed is IL1R1; the disease is neoplasm.