In WT steatotic livers, we detected an increase in CD45+CD11b+Ly6ChighLy6G−F4/80− cells, which have been shown to be precursors of myeloid-derived suppressor cells, promoting tumor growth and suppressing immune cell functions in the microenvironment.29, 31, 42 These cells are recruited through CXCL1 and CXCL2, which are produced by hepatocytes under inflammatory conditions in response to IL-1α/β.11 The gene discussed is IL1A; the disease is neoplasm.