CCND1 and neoplasm: Furthermore, the hepatic expression of Ki-67, which is strongly associated with tumor cell proliferation and growth, seemed to be increased in WT steatotic livers than in those from Il1r1Hep−/− mice (Figure 3D), whereas quantitative real-time-PCR analysis detected similar gene expression levels of Ki-67 and the proto-oncogene cyclin D1 in both genotypes (Figure 3E).