The importance of the RLRs in inducing IFN responses means that their dysregulation can lead to excessive inflammation and autoimmunity, such as in type I diabetes (T1D), systemic lupus erythematosus (SLE), and Singleton‐Merten syndrome (SMS) and Aicardi‐Goutieres Syndrome (AGS) [166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178]. Here, IFNA1 is linked to Aicardi-Goutieres syndrome.