While not known to bind viral RNA directly, DDX50 binds TRIF and enhances phosphorylation and activity of both NF‐κB and IRF3 following poly(I:C) transfection or infection with dengue virus (DENV), SeV, HSV‐1, or vaccinia virus (VACV) [100, 101]. The gene discussed is NFKB1; the disease is infection.