SPTSSA and acne: Topical application of a probiotic Lactobacillus plantarum GMNL6 in acne individuals has the potential to significantly enhance collagen production and promote the expression of the gene associated with serine palmitoyltransferase small subunit A. Furthermore, this application may lead to a reduction in melanin synthesis, the prevalence of Staphylococcus aureus biofilm, and the proliferation of C acnes.