In this study we scrutinized the major pathways involved in postprandial nutrient handling in biopsy-proven MASH patients with or without CKD: our findings disclosed for the first time an altered postprandial GLP-2/LPS/NF-kB pathway response as a distinct pathogenic feature of renal disease in MASH. Here, GCG is linked to metabolic dysfunction-associated steatohepatitis.