The same taxonomical abundance pattern was found for Lachnospiraceae, Bacteroides ovatus, and Parabacteroides in male mice carrying the Atg16l1 T300A polymorphism before and after Dextran Sulfate Sodium-induced inflammation, and stool transplantation of active CD patients into germ-free mice.65 Interestingly, many taxa that we found as increased or decreased in Atg16l1∆IEC pregnant mice in trimester 3 have been previously described to have a role in intestinal inflammation, specifically in Crohn’s disease. The gene discussed is ATG16L1; the disease is Cowden disease.