Roseburia intestinalis has been shown to protect against intrahepatic cholestasis during pregnancy (ICP) by restoring intestinal barrier function, reducing Th17 cells, and increasing Treg cells in ICP rats.85 This modulation of immune cell types, crucial for fetal tolerance, mirrors findings in TNBS-induced colitis in mice, where R. intestinalis increased anti-inflammatory IL-10 and decreased pro-inflammatory IL-17.68,86. The gene discussed is IL10; the disease is pregnancy.