Turicibacter sanguinis has been isolated from a febrile patient with acute appendicitis.76 In a mouse model with depletion of CD8+ T cells, Turicibacter was found to increase in abundance,77 while it was found low in mice lacking TNF expression prior colitis induction.78 In contrast to our results, Adlercreutzia spp. Here, CD8A is linked to appendicitis.