Various studies have shown that KDM4A/JMJD2A, KDM4B/JMJD2B, and/or KDM4C/JMJD2C are overexpressed in breast cancer, colorectal cancer, lung cancer, prostate cancer, and other tumors and are essential for the efficient growth of cancer cells (122, 123). Here, KDM4B is linked to Familial prostate cancer.