KDM4A and Familial prostate cancer: Various studies have shown that KDM4A/JMJD2A, KDM4B/JMJD2B, and/or KDM4C/JMJD2C are overexpressed in breast cancer, colorectal cancer, lung cancer, prostate cancer, and other tumors and are essential for the efficient growth of cancer cells (122, 123).