In addition, the expression of c-Myc and Max mRNA was upregulated in the spleen macrophages of CCl4-induced liver fibrosis mice (Figure 4A), and the expression of phosphorylated c-Myc protein was increased in the spleen macrophages of the model mice compared with the control group (P < 0.05, Figure 4B). Here, MYC is linked to Hepatic fibrosis.