The liver of CCl4 and TTA model mice showed evident inflammatory cell infiltration and collagen fiber proliferation than the control group; c-Myc KO model mice showed more severe liver inflammation, and the spleen of the model mice showed evident disorder of splenosome marginal area (WT-CCL4 vs KO KO-CCL4; WT-TAA vs KO-TAA) (Figures 5G, J; Supplementary Figure S6D). This evidence concerns the gene CCL4 and Hepatitis.