STAT3 and acute respiratory distress syndrome: Therefore, to validate whether IL-10 secreted by pMSCs promotes the anti-inflammatory effect in ALI by activating STAT3, we used overexpression lentivirus and siRNA to interfere with the expression of IL-10, and IL-10R neutralizing antibody and STAT3 inhibitor (5,15-DPP) to regulate the IL-10/STAT3 signaling pathway.