provided the results of a multicenter genome-wide association study (GWAS) focusing on the analysis of HCV-related cryoglobulinemia at the genome level which revealed a significant association between cryoglobulinemic vasculitis and the presence of single nucleotide polymorphisms (SNPs) in the vicinity of the NOTCH4 and MHC class II genes on chromosome 6 (43). This evidence concerns the gene NOTCH4 and cryoglobulinemia.