But we observed published gene sets, either directly related to PRC2 targets or indirectly regarding H3K27me3, to be upregulated in NF1 and PRC2-deficient iHSCs, including PASINI_SUZ12_TARGETS_UP from a study on mouse embryonic stem cells with loss of Suz1239 and a study of prostate cancer cells after EZH2 knockdown (KONDO_EZH2_TARGETS).40 The gene discussed is EZH2; the disease is prostate cancer.