NF1 and malignant peripheral nerve sheath tumor: Increases in RAS-MAPK-dependent gene expression after PRC2 loss have been described and hypothesized to contribute to malignant transformation to MPNST.2,6 GSEA, using Hallmark gene sets, revealed genes upregulated by KRAS activation (HALLMARK_KRAS_SIGNALING_UP) and downregulated by KRAS activation (HALLMARK_KRAS_SIGNALING_DN) enriched in NF1 and PRC2-deficient lines compared with NF1-deficient only lines (Supplementary Table S3).