IFNG and neoplasm: Other groups have reported IFN-γ signaling, antigen presentation, and regulation of MHC class I and II expression which are markedly reduced when PRC2 is lost.7 Some suggest PRC2 regulates these genes and decreases tumor immunogenicity.8 GSEA with Gene Ontology (GO) terms revealed these previously identified were found to be upregulated in our PRC2-deficient engineered iHSCs, such as adaptive immune response, B-cell receptor signaling pathway, antigen binding, and activation of innate immune response (Supplementary Table S3).