For example, γ-secretase also cleaves CD44 and generates a tumor-promoting cytoplasmic cleavage product, commonly expressed in MPNSTs.64 Some evidence supports γ-secretase cleaving cadherins which activate WNT signaling.65 We, therefore, speculate nirogacestat may be more effective in treating MPNST-G2 which is characterized by WNT hyperactivation.10 These ideas must be tested further using in vivo models of MPNSTs. The gene discussed is CDH17; the disease is malignant peripheral nerve sheath tumor.