IDH1 and central nervous system cancer: Since we did not perform in-depth sequencing and molecular profiling, including the search for the CDKN2A homozygous deletion in grade 3 oligodendrogliomas, IDH-mutant, and 1p19q-codeleted, we cannot exclude a molecular imbalance between the surgery and the oncological groups.40 By focusing on newly diagnosed grade 3 gliomas, IDH-mutant amenable to a large function-based resection, the present results cannot be extrapolated to other diffuse gliomas, including grade 4 astrocytomas, IDH-mutant, to biopsied cases, and to high-risk patients.