IDH1 and central nervous system cancer: Based on these results and on our own clinical experience, we have already proposed a watch-and-wait approach following maximal resection in selected cases of high-grade diffuse gliomas.35 In the present series, we reported our preliminary experience in newly diagnosed supratentorial grade 3 glioma, IDH-mutant according to the 2021 WHO classification treated with maximal safe function-based awake resection followed by a watch-and-wait approach and no early adjuvant therapy.