CHML and diffuse large B-cell lymphoma: Meantime, DENND1A expression was positively correlated with AKT1, AKT2, AKT3, RAB35, and CHML. Recent work suggested constitutive activation of the PI3K/protein kinase B (AKT) pathway that plays a crucial role in mediating growth, proliferation, and cell survival in a substantial number of DLBCL patient samples (Langmead and Salzberg, 2012; Bi et al., 2022).