In our study, DENND1A was highly enriched in hydroxymethylation in the DLBCL patients (p = 4.7e-08) (Figure 5A) and its mRNA expression level in the TCGA-DLBC dataset was consistent with the hydroxymethylation level in our data-set (Figure 5B). The gene discussed is DENND1A; the disease is diffuse large B-cell lymphoma.