NR1H2 and cystic fibrosis: The clinical associations between dysfunction of LA, AA, and DHA and the CF symptomatology related to the membrane proteins CFTR and ENaC, as well as to the nuclear receptor LXRβ, supported by different observational, experimental, and animal studies as outlined in this review, suggest that further studies on the lipid abnormalities are relevant, and may open for new and even cheap concepts for additional treatment.