Moreover, RSV supplementation (7.5–15.6 mg/kg/bw) alone (Gómez‐Zorita et al. 2013), to HFFD (42%kcal fat, 20% w/v fructose) (Trusov et al. 2021) or to mild–moderate AD patients (Moussa et al. 2017) showed increased plasma IL‐10 (Trusov et al. 2021) and decreased serum/plasma TNF‐α, MCP‐1 (Gómez‐Zorita et al. 2013), IL‐12p40, and IL‐12p70 (Moussa et al. 2017) as indicators of reduced systemic inflammation (Gómez‐Zorita et al. 2013; Moussa et al. 2017; Trusov et al. 2021). This evidence concerns the gene TNF and Alzheimer disease.