In terms of gut–muscle axis, gut microbiota may participate in the occurrence of sarcopenia by modulating the butyrate and bile acid synthesis metabolism, inducing chronic low‐titer inflammatory reaction, promoting the insulin resistance, regulating muscle synthesis metabolism, affecting the host immune system, damaging tight junctions of intestinal epithelial cells, and enhancing intestinal permeability through various pathways (Nardone et al. 2021; Prokopidis et al. 2020). This evidence concerns the gene INS and sarcopenia.