Apocynin treatment‐mediated cardioprotection and antifibrotic activity were also supported by other studies where apocynin treatment showed ameliorative effect by preventing cardiac remodeling and fibrosis in diabetic rats (Rosa et al., 2016), angiotensin‐II‐induced hypertension in mice (Li et al., 2013), and pressure overload‐induced cardiomegaly in rats (Liu et al., 2010). This evidence concerns the gene AGT and hypertensive disorder.