Paeoniflorin has active impacts in decreasing the serum contents of corticosterone, corticotropin-releasing hormone, and adrenocorticotropic hormone and increasing serotonin and 5-Hydroxyindoleacetic acid in the prefrontal cortex and hippocampus in post-traumatic stress disorder mice (Qiu et al., 2018). The gene discussed is CRH; the disease is post-traumatic stress disorder.