TGFBR1 and cancer: The one group is TGFBR2 and TGFBR1. The second group is RIOK1 and CSNK2A1. Both RIOK1 [30,31] and CSNK2A1 [32,33] are involved in the regulation of PI3K-AKT pathway, promoting cancer cell migration and invision through the PI3K-AKT signaling pathway, indicating an interaction between the PI3K-AKT and TGF-β pathways.