Wu et al. established HCC cell lines with PKMYT1 knockdown and found that PKMYT1 knockdown reduced the phosphorylation levels of p38 MAPK, ERK, and PI3K/Akt/mTOR, thereby inhibiting protective autophagy, inducing apoptosis, and ultimately inhibiting HCC progression (Wu et al., 2023). The gene discussed is PKMYT1; the disease is hepatocellular carcinoma.