TPH1 and chronic kidney disease: Poricoic acid A (PAA), derived from Poria cocos, has been identified as a modulator of TPH-1 expression, demonstrating its efficacy in attenuating renal fibrosis (Chen et al., 2020b), as well as enhancing melatonin’s inhibitory effects on the transition from AKI to CKD (Chen et al., 2019a).