TPH1 and renal fibrosis: He believes that Poricoic acid A (Chen et al., 2019b) in Poria cocos serves as a regulator of TPH-1 expression (Chen et al., 2020a; Chen et al., 2019b), inhibiting renal fibrosis, stabilizing the regulatory protein of B-catenin, and mediating B-catenin transcription (Wang et al., 2018a) and natural products (including isolated compounds, crude extracts, and traditional Chinese herbal formulas) to regulate RAS (Yang et al., 2019) can inhibit the accumulation of ECM in HK-2 cells and alleviate podocyte damage and fibrosis (Chen et al., 2017).