Poricoic acid A (PAA), derived from Poria cocos, has been identified as a modulator of TPH-1 expression, demonstrating its efficacy in attenuating renal fibrosis (Chen et al., 2020b), as well as enhancing melatonin’s inhibitory effects on the transition from AKI to CKD (Chen et al., 2019a). The gene discussed is TPH1; the disease is renal fibrosis.