Multiple studies have demonstrated that SOX6 exerts its tumor-suppressive role by downregulating the Wnt/β-catenin signaling pathway (Chen et al., 2020; Zeng and Chen, 2023; Dong et al., 2018), which plays a pivotal role in the initiation and progression of various cancers (Zhang et al., 2016; Han et al., 2017; Valenta et al., 2012; Kahn, 2014). This evidence concerns the gene SOX6 and cancer.