ABHD1 and Hyperglycemia: First, in addition to validation in the human retina database and endothelial cell lines, we will further refine the in vivo experiments, carry out ABHD1-specific gene knockout in mice, and further construct models of hyperglycemia and hypoxia to simulate diabetic status and then observe the effect of ABHD1 knockout on DR fundus findings such as retinal vascular leakage and neovascularization.