SPHK1 and cancer: According to this, compounds (12, 14–17, 19, 20) may be proposed as potent anticancertherapeutics for further in vitro investigations.Moreover, in silico techniques were used to determinethe binding pattern of the compounds in the active site of the proteins,including hCAs and hChEs, and the selected cancer drug targets suchas SphK1 and CDK6.