NOP56 and hepatocellular carcinoma: In summary, our study demonstrates that NOP56 as a core protein of box C/D snoRNPs is a poor prognostic marker for HCC, it has an important role in regulating the formation and function of the box C/D snoRNPs complex, and its knockdown reduces 2′-O-methylation modification of rRNA and inhibits cell proliferation and promotes cell apoptosis of HCC.