Currently, there are relatively few literature sources on LACC1. According to our research, LACC1-related genes are primarily enriched in metabolic pathways, such as the Hippo signaling pathway and PI3K-Akt signaling pathway, and LACC1 expression is down-regulated in mice with obesity and NAFLD. Here, LACC1 is linked to obesity due to melanocortin 4 receptor deficiency.