This review summarizes the distribution characteristics of microvessel density (MVD) in HAE lesions at this stage, the biological regulation of HIF1 a and VEGFA overexpression in angiogenesis in HAE, and the related research progress of the effect of BMP9-ID1 signaling pathway on HIF-1α and VEGFA expression with the aim of elucidating new directions for molecular biology research and molecular targeted therapies for HAE (Appendix Table 1). Here, HIF1A is linked to hereditary angioedema.