Although the mechanism by which angiogenesis is promoted requires further research, it is a new breakthrough in understanding the regulation axis of the HIF-1α/VEGFA/VEGFR signaling pathway, thus supporting the targeted treatment of hepatocellular carcinoma and of HAE owing to its similarity with hepatocytes (Figure 1) (Appendix Table 1). The gene discussed is KDR; the disease is hereditary angioedema.