HIF1A and hepatocellular carcinoma: Wang W (35) found that there was a significant positive correlation between MVD and HIF-1α and VEGF, as well as between HIF-1α and VEGF levels by establishing an animal model of hepatocellular carcinoma, which further proved that HIF-1α and VEGF play an important role in the occurrence of hepatocellular carcinoma and participate in the formation of new blood vessels in hepatocellular carcinoma.