Through a large number of animal experiments and the study of the protein expression of angiogenesis factors in human liver tissue, angiogenesis-related factors were found to be highly expressed in the peripheral infiltration area of HAE lesions; thus, angiogenesis in the peripheral infiltration area of HAE lesions may be highly correlated with the conduction of HIF-1α/VEGFA/VEGFR signaling pathway. This evidence concerns the gene HIF1A and hereditary angioedema.