This review summarizes the distribution characteristics of microvessel density (MVD) in HAE lesions at this stage, the biological regulation of HIF1 a and VEGFA overexpression in angiogenesis in HAE, and the related research progress of the effect of BMP9-ID1 signaling pathway on HIF-1α and VEGFA expression with the aim of elucidating new directions for molecular biology research and molecular targeted therapies for HAE (Appendix Table 1). This evidence concerns the gene GDF2 and hereditary angioedema.