Although the mechanism by which angiogenesis is promoted requires further research, it is a new breakthrough in understanding the regulation axis of the HIF-1α/VEGFA/VEGFR signaling pathway, thus supporting the targeted treatment of hepatocellular carcinoma and of HAE owing to its similarity with hepatocytes (Figure 1) (Appendix Table 1). This evidence concerns the gene HIF1A and hereditary angioedema.